Rabivet PII

Rabivet PII (Inactivated Animal Rabies Vaccine) is produced via cell culture in Institute Pasteur of Iran at viral vaccine department. This vaccine is an injectable suspension of inactivated rabies virus prepared from Pasteur strain PV2061.

The virus is harvested from infected BHK-21 C13 cell line, concentrated by ultrafiltration and eventually inactivated by beta-propiolactone.


Generic name

Inactivated Animal Rabies Vaccine, cell cultured.


Trade name

Rabivet PII


Dosage Form

 Red to pink injectable suspension, containing adjuvant (Alhydrogel).

Single dose vial of 1 ml (≥1 IU/ml) and in the near future 5 dose vial of 5 ml (≥1 IU/ml).



Rabivet PII vaccine contains the rabies virus antigens in liquid DMEM (Dulbecco's Modified Eagle's Medium) which adsorbed on aluminum hydroxide, preserved with thiomersal and stabilized with bovine serum albumin.


 Administration Route

Usual dose (according to the vaccination program for the target animal and based on the protocols of the country's veterinary organization and the veterinarian's opinion): The first vaccination is done after 3-4 months (when maternal antibody level is reduced) and the vaccine is administered as an annual booster.

The vaccine must be gently shaken before injection and administered by intramuscular (IM) injection.


Side Effects

In some limited cases, there is a possibility of slight swelling at the injection site, which usually resolves on its own within a few days. There is no change in body temperature after vaccination.



Keep out of reach of children, uninformed persons and animals.

Vaccinate only healthy animals in order to obtain the best possible immune response.

Packaging Specifications:

Primary packaging:

Single dose: 2R glass vial (Type I), 13 mm boromobutyl rubber.

Secondary packaging:

Single dose: 13 mm flip-top aluminum cap, specific label, medium box with divider and brochure.



Package Size


Each box contains 25 vials.





Clinical Particulars


Rabies is a serious infection of the brain and central nervous system. It is rare in domestic animals, but when it is passed to them, it is usually because they have been bitten by a wild creature that has been infected with the disease – most often foxes, bats, and stray dogs. This is because the infectious virus particles are retained in the saliva of the infected animal. Once bitten, the virus passes into animal body where it replicates in the cells of the muscles and the nerve fibers, eventually traveling to the central nervous system. The virus does not reach full strength immediately and instead can take up to 4 weeks to develop. However, once the animal reaches the point that the symptoms become apparent, the virus spreads rapidly and a painful death can occur as quickly as within 10 days.


Vaccination makes it possible to protect animals, and indirectly people, to avoid painful and debilitating symptoms and a quick and unpleasant death


The first vaccination of animals is recommended by one dose of vaccine from 3 months of age. To obtain a permanent protection, booster dose is necessary once every year.


International movement of animal: National importing authorities should acquire an international veterinary certificate attesting that the animal was not showing signs of rabies at time of shipment, was permanently identified, vaccinated or revaccinated and subjected to a positive serological test prior to shipment. OIE international standards should be followed.



Proposed Shelf Life


One year after production date (at 2-8°C).



Proposed Storage Condition


Store between +2°C to +8°C (in refrigerator). Do not freeze. Protect from light.